Ten Years of Progress in GW/P Body Research
GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational r
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Edward K.L. Chan • Marvin J. Fritzler Editors
Ten Years of Progress in GW/P Body Research
Editors Edward K.L. Chan Department of Oral Biology University of Florida Gainesville, FL, USA
Marvin J. Fritzler Department of Medicine and Medical Biochemistry University of Calgary Calgary, AB, Canada
ISSN 0065-2598 ISBN 978-1-4614-5106-8 ISBN 978-1-4614-5107-5 (eBook) DOI 10.1007/978-1-4614-5107-5 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012952091 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The field of RNA degradation has attained significant recognition over the past decade for many reasons. One is that new technologies and methods have been devised that allow detailed molecular mechanisms to be elucidated and another is the success of using the genetically tractable budding yeast. During this period, investigators have noted the differences as well as the similarities between yeast and mammalian mechanisms of RNA turnover. One common feature is that the RNA processing machinery is localized to cytoplasmic particles that regulate mRNA translation and decay. These include most prominently the cytoplasmic gl
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