Terbinafine
- PDF / 141,212 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 46 Downloads / 141 Views
1
S
Stevens-Johnson syndrome and aggravation of systemic lupus erythematosus: case report A 25-year-old woman had a 4-year-history of systemic lupus erythematosus without renal involvement, which was stable with corticosteroid and chloroquine therapy. Seven days after starting terbinafine [dosage not stated] for onychomycosis, she developed a skin eruption associated with cheilitis of her mucous membranes and bilateral conjunctivitis. She then experienced epidermolysis involving 10% of her skin area and was diagnosed with Stevens-Johnson syndrome. Laboratory investigations were indicative of massive haematuria and proteinuria, a renal biopsy revealed signs of class III lupus glomerulonephritis, and antihistone antibodies were highly positive. Chloroquine was restarted and she received corticosteroids and cyclophosphamides. Her lupus and skin eruption outcomes were favourable. Author comment: The concomitant occurrence of this patient’s skin eruption and lupus relapse on treatment with terbinafine suggest the involvement of a shared immunological mechanism. Terrab Z, et al. Stevens-Johnson syndrome and worsening of a systemic lupus induced by terbinafine. Annales de Dermatologie et de Venereologie 133: 463-466, No. 5, Part 1, May 2006 [French; summarised from an English abstract] 801044214 Morocco
0114-9954/10/1119-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 16 Sep 2006 No. 1119
