The association between bone age advancement and insulin in prepubertal children with obesity
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POSTER PRESENTATION
Open Access
The association between bone age advancement and insulin in prepubertal children with obesity Hae Sang Lee*, Hwal Rim Jeong, Eunbyul Kwon, Jin Soon Hwang From 8th APPES Biennial Scientific Meeting Darwin, Australia. 29 October – 1 November 2014 Aims Obesity is associated with bone age (BA) advancement of unclear etiology. In animal study, insulin may directly modulate skeletal growth. Our objective was to investigate the association with BA maturation and insulin levels in children with overweight and obesity.
doi:10.1186/1687-9856-2015-S1-P71 Cite this article as: Lee et al.: The association between bone age advancement and insulin in prepubertal children with obesity. International Journal of Pediatric Endocrinology 2015 2015(Suppl 1):P71.
Methods In this cross-sectional study of 103 prepubertal children, anthropometric data and hormonal values during oral glucose tolerance test were measured. Subjects were divided into two groups by the difference between BA and chronological age (CA) (noted as BA-CA). Results The study population included 49 (47.6%) males and 54 (52.4%) females with a mean age of 7.6 ± 1.6 years. The advanced bone age group defined as BA-CA>1 year (n=53) had significantly higher HOMA-IR, fasting insulin levels and lower quantitative insulin sensitivity check index (QUICKI). Also, BA-CA was significantly correlated with fasting insulin (r=0.315, P
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