The association between diazinon exposure and dyslipidemia occurrence: a systematic and meta-analysis study
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REVIEW ARTICLE
The association between diazinon exposure and dyslipidemia occurrence: a systematic and meta-analysis study Hamed Aramjoo 1 & Tahereh Farkhondeh 2,3 & Micheal Aschner 4 & Kobra Naseri 2,3 & Omid Mehrpour 5,6 & Parisa Sadighara 7 & Babak Roshanravan 8 & Saeed Samarghandian 9 Received: 11 June 2020 / Accepted: 21 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The effects of diazinon (DZN), an organophosphate pesticide, on lipid profiles have been extensively reported. However, controversy on this issue persists. Here, we performed a systematic and meta-analysis study to investigate the association between DZN exposure and dyslipidemia in rodents and fish species. This systematic review was prepared according to the PRISMA guidelines. Main databases, including Google Scholar, Scopus, PubMed, Ovid MEDLINE, and Web of Science, were systematically searched through March 4, 2020. The risk of bias was evaluated with the SYRCLE’s RoB tool. Once all articles were assessed for scientific quality, a random-effects model was applied to perform a pooled analysis. I2 and Q test were used to assess the heterogeneity between articles, and Forest plots, indicating point and pooled estimates, were drawn. Twenty-eight articles were included; between them, 13 publications were selected for meta-analysis. Random-effects meta-analysis showed low heterogeneity between the articles. A pooled analysis indicated that DZN significantly increased total cholesterol levels (95% CI: 0.86–3.79; Z = 3.10; p = 0.002), triglyceride (95% CI: 0.38–3.22; Z = 2.48; p = 0.09), low-density lipoprotein cholesterol (95% CI: 0.25–2.85; Z = 2.34; p = 0.7) in the DZN vs. control groups. In addition, DZN significantly decreased high-density lipoprotein cholesterol (95% CI: − 2.92, − 0.42; Z = 2.62; p = 0.07) in the DZN vs. control groups. No publication bias was observed. Our findings suggest that DZN induces dyslipidemia in rodents and fish species in a dose-dependent manner. Keywords Rodents . Fish species . Lipid profile . Diazinon . Organophosphate pesticides
Introduction Dyslipidemia is one of the metabolic disorders, which is manifested by an abnormal serum lipid level, including an increase in total cholesterol (TC), an increase in low-density lipoprotein cholesterol (LDL-C) triglyceride (TG), and a decrease in
high-density lipoprotein cholesterol (HDL-C) (Perk et al. 2012). Dyslipidemia represents an important risk factor for several underlying diseases, including cardiovascular disease (CVD), type 2 diabetes, and atherosclerosis. Worldwide, 33.1% of annual deaths are related to CVD and stroke (American Diabetes Association 2020; Townsend et al.
Responsible Editor: Lotfi Aleya * Saeed Samarghandian [email protected] 1
Student Research Committee, BSc Student in Medical Laboratory Science, Birjand University of Medical Sciences, Birjand, Iran
2
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran
3
Faculty of Pharmacy, Bi
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