The association between gallstone disease and metabolic syndrome related abnormalities: a systematic review and meta-ana
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REVIEW ARTICLE
The association between gallstone disease and metabolic syndrome related abnormalities: a systematic review and meta-analysis Peiwu Jiang 1 & Zhongkai Ni 2 & Shifei Huang 1 & Xiaowen Li 2 & Ye Li 2 & Hai Huang 1,2 Received: 5 March 2020 / Accepted: 28 October 2020 # Research Society for Study of Diabetes in India 2020
Abstract Background Bile excretion is one of the important metabolite excretion pathways of the human body. In recent years, it has been reported that metabolic diseases are associated with the occurrence of gallstone disease. The main purpose of this systematic review is to examine the relationship between metabolic syndrome and cholelithiasis, including components of the metabolic syndrome such as abnormal blood glucose regulation, hyperlipidemia, and obesity. Methods PubMed, Cochrane Library, and Embase were searched for all English language articles for the following relevant keywords: Metabolic Syndrome, Reaven Syndrome X, Biliary Calculi, Cholelithiasis Gallstones. Case-control study, crosssectional study, and cohort study were included. Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The pooled mean differences of the outcome measures were compared between patients with and without metabolic syndrome. Results After screening, a total of 5 cross-sectional studies and 1 cohort study were included in the meta-analysis. The 6 studies evaluated a total of 49,101 people, of whom 9055 had metabolic syndrome and 2308 had gallstone disease. There is a significant correlation between metabolic syndrome and gallstone disease (z = 6.65, p = 0.000), and it’s more significant in female. All studies displayed increasing odds of gallstone disease with increasing number of metabolic syndrome traits, where patients with three or more metabolic syndrome traits tended to have a higher prevalence of nephrolithiasis. Conclusions Our review shows a definite association of metabolic syndrome with gallstone disease, and the more the components of metabolic syndrome, the higher the prevalence of gallstone disease. Although not as obvious as women, men also support this conclusion. Keywords Gallstone disease . Insulin resistance . Meta-analysis . Metabolic syndrome
Background Gallstones disease (GSD) is the most common digestive disease needing admission to hospital in the West. With a prevalence of 10–15% in adults in Europe and the USA, 5–20% in Asian populations, gallstone disease is one of the most common and most expensive to treat among the digestive
A pre-print version have been posted at Research Square on 19 Feb, 2020. * Hai Huang [email protected] 1
Department of General Surgery, Hangzhou Dingqiao Hospital, Hangzhou Zhejiang, People’s Republic of China
2
Department of General Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou Zhejiang, People’s Republic of China
disorders that need admission to hospital [1–4]. It constitutes a major health burden that has increased more than 20% over the last 3 decade
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