The association between exposure to radiation and the incidence of cataract
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ORIGINAL PAPER
The association between exposure to radiation and the incidence of cataract Orly Weinstein . Maayan Yitshak Sade . Ilan Shelef . Victor Novack . Muhammad Abu Tailakh . Jaime Levy
Received: 17 March 2020 / Accepted: 17 August 2020 Ó Springer Nature B.V. 2020
Abstract Objective To examine the association between exposure to radiation from computed tomography (CT) studies and the incidence of cataract. Methods In a nested case–control study, all cataract cases and their matched controls were sampled from a retrospective cohort of Israeli residents who underwent CT scans or ultrasonic tests in Soroka Medical Center, Beer-Sheva, Israel, between the years 1996 and 2014. The risk of cataract associated with head, Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10792-020-01572-5) contains supplementary material, which is available to authorized users. O. Weinstein Ophthalmology Department, Soroka University Medical Center, Beer-Sheva, Israel O. Weinstein Ministry of Health, Jerusalem, Israel O. Weinstein V. Novack M. Abu Tailakh Recanati School for Community Health Professions, Department of Nursing, Faculty of Health Sciences, BenGurion University of the Negev, Beer-Sheva, Israel M. Yitshak Sade V. Novack M. Abu Tailakh Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel
neck or the rest of the body CT was assessed using Poisson survival analysis. Results The nested matched sample included 3841 cataract cases and their age- and sex-matched controls (n = 228,743). CT radiation exposure was more frequent in the cataract group, with 9.7% head CT, 1.2% neck CT and 6.6% other CT, compared to 5%, 0.7% and 3.7% among person-years without cataract (p \ 0.001). In a multivariate analysis, a similar increased risk of cataract associated with head (hazard ratio (HR): 1.24, 95% confidence interval (CI): 1.11; 1.38) and other CT (HR: 1.25, 95% CI: 1.10; 1.43) was found. No association with neck CT (HR: 1.07, 95% CI: 0.80; 1.43) was observed. M. Yitshak Sade Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA I. Shelef Radiological Institute, Soroka University Medical Center, Beer-Sheva, Israel J. Levy (&) Department of Ophthalmology, Hadassah Medical Center, P.O. Box 12000, 91120 Jerusalem, Israel e-mail: [email protected]
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Conclusion In our study population, a similar risk of cataract with head, neck or the rest of the body CT was detected. Keywords Cataract Computed tomography Ultrasound Radiation
exposure scale makes the estimation of the cumulative exposure difficult [12–15, 17]. To overcome all previous limitations, a large population retrospective study was conducted during a long period to examine the association between exposure to radiation from CT studies and the incidence of cataract.
Introduction
Methods
Cataract is a main ocular problem in the Western world, an
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