The association between health-related quality of life and achievement of personalized symptom goal
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ORIGINAL ARTICLE
The association between health-related quality of life and achievement of personalized symptom goal Keita Tagami 1,2 & Takashi Kawaguchi 3 & Tomofumi Miura 2,4 & Takuhiro Yamaguchi 5 & Yoshihisa Matsumoto 2 & Yuki Sumazaki Watanabe 2 & Yuko Uehara 2 & Ayumi Okizaki 2 & Akira Inoue 1 & Tatsuya Morita 6 & Hiroya Kinoshita 2,7 Received: 8 August 2019 / Accepted: 17 January 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The aim of study was to explore the potential association between patient’s self-reported physical symptom management goals as personalized symptom goal (PSGs) and health-related quality of life (HRQOL) in cancer patients. The secondary outcome was to investigate the relationship between number of physical symptoms not achieving the PSGs and HRQOL in cancer patients. Methods This single-center prospective observational study comprised 140 consecutive outpatients. We evaluated the PSGs and HRQOL using the Functional Assessment of Cancer Therapy–General (FACT-G). Patients were administered a self-report questionnaire, including reports on their physical symptom intensity and PSGs using Edmonton Symptom Assessment System-revised (ESAS-r) scores. We investigated the correlation between PSGs achievement (ESAS-r score ≤ PSG score) and FACT-G total scores, and relationship between and number of physical symptoms not achieving the PSGs (ESAS-r score > PSG score) and FACT-G total scores. Results The patients who did not achieve PSGs of pain, tiredness, lack of appetite, and shortness of breath had a lower FACT-G total score (p < 0.05). Multivariate linear regression showed that higher number of physical symptoms not achieving the PSGs correlated with lower FACT-G scores (decreasing by 1.826 points for each such symptom, p < 0.01). Predictors of increased number of physical symptoms not achieving the PSGs were younger age and a higher symptom intensity of anxiety. Conclusion PSGs achievement was associated with HRQOL in cancer patients. Additionally, the number of unachieved PSGs were independent determinant of poor HRQOL, particularly in younger cancer patients and those with higher symptom intensity of anxiety. Keywords Cancer patients . Personalized symptom goal . Physical symptom . Quality of life . Symptom management
* Keita Tagami [email protected] 1
Department of Palliative Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
2
Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan
3
Department of Practical Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan
4
Division of Biomarker Discovery, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan
5
Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan
6
Department of Palliative and Supportive Care, Palliative Care Team, Seirei Mikatahara General Hospital, Hamamatsu, Japan
7
Department of Palliative Care, Tokatsu Hospital, Nagareyama,
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