Association between health-related quality of life outcomes and pulmonary function testing
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Association between health‑related quality of life outcomes and pulmonary function testing Hiroko Matsumoto1,2 · Gerard Marciano1 · Gregory Redding3 · June Ha1 · Scott Luhmann4 · Sumeet Garg5 · David Roye1 · Klane White6 · Pediatric Spine Study Group Received: 23 June 2020 / Accepted: 10 August 2020 © Scoliosis Research Society 2020
Abstract Introduction Investigations in associations between subjective health-related quality of life (HRQoL) measures and objective clinical assessments in patients with early-onset scoliosis (EOS) are limited. The purpose of this study is to investigate the association between pulmonary function rated by parents and pulmonary function testing (PFT) in patients with EOS. Materials/methods In this cross-sectional study, patients with EOS at any stage of treatment from 2011 to 2018 were identified in 2 registries including 33 centers. Parents’ perception of pulmonary function was evaluated using pulmonary function (PF) domain in the Early-Onset Scoliosis 24 item Questionnaire (EOSQ-24). PFT measures included FVC% predicted, FEV1/ FVC, and TLC% predicted. All PFT predicted values utilized arm span. PFT and EOSQ-24 questionnaire were completed within 180 days of each other with an average day difference of 26 days. Results 176 patients (mean age: 10.4 years old, female: 56%) were identified. 33% of patients were of congenital/structural etiology, 27% neuromuscular, 26% syndromic, and 14% idiopathic. Wide variance and lower scores of PF domain were reported by parents at lower FVC% predicted values (
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