The Basics of Cancer Immunotherapy
This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immun
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The Basics of Cancer Immunotherapy
The Basics of Cancer Immunotherapy
Haidong Dong • Svetomir N. Markovic Editors
The Basics of Cancer Immunotherapy
Editors Haidong Dong Department of Urology, Department of Immunology College of Medicine, Mayo Clinic Rochester, MN, USA
Svetomir N. Markovic Department of Oncology, Department of Medicine/Division of Hematology, Department of Immunology College of Medicine, Mayo Clinic Rochester, MN, USA
ISBN 978-3-319-70621-4 ISBN 978-3-319-70622-1 (eBook) https://doi.org/10.1007/978-3-319-70622-1 Library of Congress Control Number: 2017961878 © Springer International Publishing AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Acknowledgements
We are grateful to the pioneers, our mentors, and colleagues in the field of cancer immunology and immunotherapy. We dedicate our book to our patients and their families for fighting cancer with us. Our research has been supported by the National Institute of Health, the National Cancer Institute, and the Mayo Foundation. We appreciate Dr. Khalid Jazieh, MBBS, for helpful review of the drafts of each chapter and in designing several graphs and suggesting the idea for the cover design. We apologize for not being able to cite all of the excellent studies and clinical trials in this field due to space limitations. Haidong Dong Svetomir N. Markovic
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Contents
1 The Basic Concepts in Cancer Immunology and Immunotherapy................................................................................ 1 Haidong Dong Why Do We Have Cancer?........................................................................ 1 How Does the Immune System Protect Us fro
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