The Big Book on Small Heat Shock Proteins
Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo,
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Robert M. Tanguay Lawrence E. Hightower Editors
The Big Book on Small Heat Shock Proteins
Heat Shock Proteins Volume 8
Series editors Alexzander A.A. Asea, Ph.D., Professor and VD for Research Innovations, Deanship for Scientific Research, University of Dammam, Dammam, Saudi Arabia Stuart K. Calderwood, Department of Radiation Oncology, Molecular & Cellular Radiation Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Heat Shock Proteins: key mediators of Health and Disease. Heat shock proteins (HSP) are essential molecules conserved through cellular evolution required for cells to survive the stresses encountered in the environment and in the tissues of the developing and aging organism. These proteins play the essential roles in stress of preventing the initiation of programmed cell death and repairing damage to the proteome permitting resumption of normal metabolism. Loss of the HSP is lethal either in the short-term in cases of acute stress or in the long-term when exposure to stress is chronic. Cells appear to walk a fine line in terms of HSP expression. If expression falls below a certain level, cells become sensitive to oxidative damage that influences aging and protein aggregation disease. If HSP levels rise above the normal range, inflammatory and oncogenic changes occur. It is becoming clear that HSP are emerging as remarkably versatile mediators of health and disease. The aim of this series of volumes is to examine how HSP regulation and expression become altered in pathological states and how this may be remedied by pharmacological and other interventions.
More information about this series at http://www.springer.com/series/7515
Robert M. Tanguay • Lawrence E. Hightower Editors
The Big Book on Small Heat Shock Proteins
Editors Robert M. Tanguay Department of Molecular Biology, Medical Biochemistry & Pathology Medical School Lab Cell & Developmental Genetics IBIS Université Laval Québec, QC, Canada
Lawrence E. Hightower Department of Molecular and Cell Biology University of Connecticut Storrs, CT, USA
ISSN 1877-1246 ISSN 1877-1254 (electronic) Heat Shock Proteins ISBN 978-3-319-16076-4 ISBN 978-3-319-16077-1 (eBook) DOI 10.1007/978-3-319-16077-1 Library of Congress Control Number: 2015940537 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the rel
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