The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic
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BioMed Central
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The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients G Koller*1, B Bondy2, UW Preuss3, P Zill2 and M Soyka4 Address: 1Psychiatrische Klinik der LMU, Substitutionsambulanz, Pestalozzistraße 2, D-80469 München, Germany, 2Psychiatrische Klinik der LMU, Neurochemie, Nußbaumstraße 7, D-80336 München, Germany, 3Johanna-Odebrecht-Stiftung, Gützkower Landstraße 69, D-17489 Greifswald, Germany and 4Psychiatrische Klinik der LMU, Nussbaumstrasse 7, D-80336 München, Germany Email: G Koller* - [email protected]; B Bondy - [email protected]; UW Preuss - [email protected]; P Zill - [email protected]; M Soyka - [email protected] * Corresponding author
Published: 25 February 2006 Behavioral and Brain Functions 2006, 2:7
doi:10.1186/1744-9081-2-7
Received: 31 October 2005 Accepted: 25 February 2006
This article is available from: http://www.behavioralandbrainfunctions.com/content/2/1/7 © 2006 Koller et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract The 5HT1A receptor is one of at least 14 different receptors for serotonin which has a role in moderating several brain functions and may be involved in the aetiology of several psychiatric disorders. The C(-1019)G 5-HT1A promoter polymorphism was reported to be associated with major depression, depression-related personality traits and suicidal behavior in various samples. The G(-1019) allele carriers are prone to depressive personality traits and suicidal behavior, because serotonergic neurotransmission is reduced. The aim of this study is to replicate previous findings in a sample of 185 Alcohol-dependent individuals. Personality traits were evaluated using the NEO FFI and TCI. History of suicidal behavior was assessed by a standardized semistructured interview (SSAGA). No significant differences across C(-1019)G 5-HT1A genotype groups were found for TCI temperament and character traits and for NEO FFI personality scales. No association was detected between this genetic variant and history of suicide attempts. These results neither support a role of C(-1019)G 5-HT1A promoter polymorphism in the disposition of personality traits like harm avoidance or neuroticism, nor confirm previous research reporting an involvement of the G allele in suicidal behavior in alcoholics. Significant associations, however, were detected between Babor's Type B with number of suicide attempts in history, high neuroticism and harm avoidance scores in alcoholics.
Background The 5-hydroxytryptamine 1A receptor (5-HT1A) is one of several different receptors for 5-hydroxytryptamine (serotonin). Serotonin has a role in moderating several brain functions and is invo
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