Association between serum levels of C-reactive protein and personality traits in women
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BioMed Central
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Association between serum levels of C-reactive protein and personality traits in women Susanne Henningsson1, Fariba Baghaei2, Roland Rosmond2, Göran Holm2, Mikael Landén3, Henrik Anckarsäter4 and Agneta Ekman*1 Address: 1Department of Neuroscience and Physiology, Section of Pharmacology, Göteborg University, P.O. Box 431, SE 405 30 Göteborg, Sweden, 2Institute of Medicine, Department of Metabolism and Cardiovascular Research, Göteborg University, Göteborg, Sweden, 3Department of Clinical Neuroscience, Section of Psychiatry S:t Göran, Karolinska Institutet, Stockholm, Sweden and 4Section of Psychiatry and Neurochemistry, Göteborg University, Göteborg, Sweden Email: Susanne Henningsson - [email protected]; Fariba Baghaei - [email protected]; Roland Rosmond - [email protected]; Göran Holm - [email protected]; Mikael Landén - [email protected]; Henrik Anckarsäter - [email protected]; Agneta Ekman* - [email protected] * Corresponding author
Published: 2 April 2008 Behavioral and Brain Functions 2008, 4:16
doi:10.1186/1744-9081-4-16
Received: 2 January 2008 Accepted: 2 April 2008
This article is available from: http://www.behavioralandbrainfunctions.com/content/4/1/16 © 2008 Henningsson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: While low-grade inflammation has consistently been observed in subjects with depression, studies on the possible relationship between inflammation and other aspects of brain function are as yet sparse. In this study, we aimed to investigate the possible association between serum levels of the inflammation marker C-reactive protein (CRP) and personality traits. Methods: In this study, serum levels of high-sensitivity CRP were determined by ELISA in a population of 270 42-year-old women recruited from the population registry who had been assessed using the Temperament and Character Inventory. Self-reported previous or ongoing depression was also recorded. Unpaired two-tailed t-tests were used for comparison between two groups and correlations were evaluated by the calculation of Pearson's r-coefficient. Results: The temperament trait harm avoidance was positively (r = 0.227, p < 0.05) and the character trait self-directedness was negatively (r = -0.261, p < 0.01) associated with serum levels of CRP (p-values corrected for multiple comparisons). The correlations between the personality traits and CRP were observed also after exclusion of subjects reporting ongoing depression (n = 26). Whereas women reporting ongoing depression showed significantly increased levels of CRP as compared to non-depressed women (n = 155), women reporting a history of depression displayed no significant difference in CRP levels as compared t
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