The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has b
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Domenico Ribatti
The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis
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Prof. Domenico Ribatti Dipartimento di Anatomia Umana e Istologia Piazza G. Cesare, 11 Policlinico Università degli Studi di Bari 70124 Bari Italy [email protected]
ISBN 978-90-481-3843-2 e-ISBN 978-90-481-3845-6 DOI 10.1007/978-90-481-3845-6 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010920248 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Acknowledgments
I express my gratitude to my wife Beatrice Nico and all the colleagues and friends involved in the researches performed in the last twenty years concerning the study of several aspects of angiogenesis and antiangiogenesis by using the CAM assay. In particular, Angelo Vacca (Bari), Marco Presta (Brescia), Enrico Crivellato (Udine), Mirco Ponzoni and Vito Pistoia (Genova), Gastone G. Nussdorfer and Diego Guidolin (Padua), Valentin Djonov (Friburg), Marius Raica and Anca Maria Cimpean (Timisoara), Sandra Liekens (Leuvan).
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Contents
1 Chorioallantoic Membrane Vasculature . . . . . . . . . . . 1.1 Chorioallantoic Membrane and Its Embryological Origin 1.2 Morphology of Chorioallantoic Membrane Blood Vessels 1.3 Morphology of Chorioallantoic Membrane Lymphatic Vessels . . . . . . . . . . . . . . . . . . . . . 1.4 A Single Blood Sinus or a Capillary Plexus Beneath the Chorionic Epithelium? . . . . . . . . . . . . . . . . 1.5 A New Model of Choriollantoic Membrane Vascular Growth, the Intussusceptive Mode . . . . . . . . . . . . 1.6 Chorioallantoic Membrane Vascular Growth . . . . . . .
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2 Chorioallantoic Membrane in the Study of Angiogenesis, Antiangiogenesis, and the Vascularization of Grafted Tissues . 2.1 Use of Chorioallantoic Membrane in the Study of Angiogenic Molecules . . . . . . . . . . . . . . . . . . . 2.2 Role of FGF-2 in Chorioallantoic Membrane Vascularization 2.3 Use of Chorioallantoic Membrane in the Study of Antiangiogenic Molecules . . . . . . . . . . . . . . . . . 2.4 Use of Chorioallantoic Membrane in the Study of Vascularization of Grafted Tissues . . . . . . . . . . . . .
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3 Chorioallantoic Membrane in the Study of Tumor Angiogenesis 3.1 Use of Chorioallantoic Membrane in the Study of Tumor Angiogenesis . . . . . . . . . . . . . . . . . . . . . 3.2 Angiogenesis and Antiangiogenesis in Multiple Myeloma . . . 3.2.1 Biological and Clinical Studi
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