Acute and chronic exposure of chick embryo to ethanol alters brain neurosteroid levels
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ORIGINAL PAPER
Acute and chronic exposure of chick embryo to ethanol alters brain neurosteroid levels Mahnaz Taherianfard & Marjan Davazdahemamy & Manzarbanoo Shojaeifard & Maryam Sharifi
Received: 25 September 2011 / Accepted: 28 June 2012 / Published online: 24 July 2012 # University of Navarra 2012
Abstract Neurosteroids are modulators of neuronal function that may play important role in brain maturation. The aim of the present investigation was to study the effect of prenatal exposure to acute and chronic ethanol on brain progesterone, estradiol, and testosterone concentration on 10th and 15th days following egg incubation. Eggs were exposed to ethanol at 10 % in chronic treatment and 70 % in acute treatment. Progesterone, estradiol, and testosterone were assayed by radioimmunoassay method. It was shown that brain progesterone level was significantly decreased (P< 0.05) in chronic ethanol group on embryonic day 10, but it was significantly decreased (P
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