The differences of clinical characteristics and outcomes between imported and local patients of COVID-19 in Hunan: a two
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RESEARCH
The differences of clinical characteristics and outcomes between imported and local patients of COVID‑19 in Hunan: a two‑center retrospective study Chang Wang1†, Lizhi Zhou2†, Juan Chen3, Yong Yang4, Tianlong Huang5, Min Fu6, Ya Li7, Daniel M. George8 and Xiangyu Chen7*
Abstract Background: The clinical characteristics and outcomes of the 2019 novel coronavirus (COVID-19) pneumonia are different in Hubei compared to other regions in China. But there are few comparative studies on the differences between imported and local patients which may provide information of the different courses of the virus after transmission. Methods: We investigated 169 cases of COVID-19 pneumonia in two centers in Hunan Province, and divided them into two groups according to epidemiological history, "imported patients" refers to patient with a clear history of travel in Wuhan within 14 days before onset, and " local patients” refers to local resident without a recent history of travel in Wuhan, aiming to analyze the difference in clinical characteristics and outcomes between the two groups. All the epidemiological, clinical, imaging, and laboratory data were analyzed and contrasted. Results: The incidence of fever on admission in imported patients was significantly higher than local patients. There was a significantly higher proportion of abnormal pulmonary signs, hypokalemia, hyponatremia, prolonged PT, elevated D-dimer and elevated blood glucose in imported patients. Compared with local patients, the proportion using antibiotics, glucocorticoids and gamma globulin were significantly higher in imported patients. The moderate type was more common in local patients, and the severe type were more frequent in imported patients. In addition, the median duration of viral clearance was longer in imported patients. Conclusions: In summary, we found that imported cases were more likely to develop into severe cases, compared with local patients and required more powerful treatments. Trial registration Registered 21st March 2020, and this study has been approved by the Medical Ethics Committee (Approved Number. 2020017). Keywords: COVID-19, SARS-CoV-2, Clinical characteristics, Outcomes, Virulence
*Correspondence: [email protected] † Chang Wang and Lizhi Zhou contributed equally to this work 7 Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China Full list of author information is available at the end of the article
Background The outbreak of COVID-19 pneumonia was recognized in December 2019 and the World Health Organization declared 2019-nCoV epidemic as a Public Health Emergency of International Concern on January 30th, 2020 [1]. As of June 15th, 2020, China has confirmed 84,778
© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s
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