The DNA Damage Response: Implications on Cancer Formation and Treatment
The book The DNA Damage Response: Implications on Cancer Formation and Treatment brings together a great collection of review articles. The articles have been written by a group of experts who have a deep knowledge of the recent advances in the
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Kum Kum Khanna · Yosef Shiloh Editors
The DNA Damage Response: Implications on Cancer Formation and Treatment
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Editors Dr. Kum Kum Khanna Queensland Institute of Medical Research Signal Transduction Laboratory 300 Herston Road Herston QLD 4006 Australia [email protected]
Dr. Yosef Shiloh Tel Aviv University Sackler School of Medicine Dept. Human Molecular Genetics & Biochemistry 69978 Tel Aviv Ramat Aviv Israel [email protected]
ISBN 978-90-481-2560-9 e-ISBN 978-90-481-2561-6 DOI 10.1007/978-90-481-2561-6 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009927008 © Springer Science+Business Media B.V. 2009 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The field of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the maintenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated system designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, transcriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to specific damaging agents, immunodeficiency, genomic instability, cancer predisposition and premature aging. The finding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving field, and the advances in our understanding of the complex network of processes that respond to DNA damage. The researchers who contributed chapters have profound knowledge of the recent advances in DNA damage signalling and repair and their implications for carcinogenesis, and are well positioned to anticipate upcoming developments in their respective fields. T
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