The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais
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ORIGINAL INVESTIGATION
The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais Suwit Chaisri1,2 · Amonrat Jumnainsong2,3 · Amornrat Romphruk2,4 · Chanvit Leelayuwat2,3 Received: 17 December 2019 / Accepted: 2 June 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Killer cell immunoglobulin-like receptors (KIRs) are cell surface receptors on natural killer (NK) cells and subsets of T cells. The interaction between KIRs and their cognate ligands (Human leukocyte antigen class I molecules, HLA class I) modulates the immune response of NK cells, in particular through clearance of virus-infected cells. Here, we investigated the effect of KIRs and HLA ligands on dengue infections and disease severity. The KIRs and HLA ligands were identified in 235 healthy controls (HC) and 253 dengue patients (DEN) using polymerase chain reaction with sequence specific primer (PCR–SSP); moreover, DEN was classified to 100 dengue fever (DF) and 153 dengue haemorrhagic fever (DHF). Risks were expressed as odds ratios (ORs) and 95% confidence intervals (CIs) with significance set at a two-tailed P value of
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