The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial
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ORIGINAL CONTRIBUTION
The effect of olive leaf extract on cardiovascular health markers: a randomized placebo‑controlled clinical trial Yala Stevens1,2 · Bjorn Winkens3 · Daisy Jonkers1 · Adrian Masclee1 Received: 10 June 2020 / Accepted: 23 September 2020 © The Author(s) 2020
Abstract Purpose Overweight and obesity are associated with many health problems, including cardiovascular disease (CVD). Evidence from previous studies has shown that extracts from olive leaves rich in olive phenolics are able to positively affect CVD risk factors, such as high blood pressure and dyslipidemia. The aim of this study was to investigate the effect of 8-week olive leaf extract (OLE) administration on blood lipid profiles in overweight/obese subjects with mildly elevated cholesterol levels. Methods In this randomized, double-blind, placebo-controlled study, 77 healthy adult overweight/obese subjects (aged 56 ± 10 years and BMI 29.0 ± 2.7 kg/m2) with total cholesterol levels of 5.0–8.0 mmol/L (5.9 ± 0.7 mmol/L) were randomly assigned to receive 500 mg of OLE (n = 39) or placebo (n = 38) for 8 weeks. In total, 74 subjects completed the entire study protocol. At baseline, after 4 weeks, and after 8 weeks of supplementation, blood lipid profiles, oxidized low-density lipoprotein (oxLDL), blood pressure, glucose, and insulin levels were assessed. In addition, liver function parameters were measured at baseline and after 8 weeks. Results OLE supplementation did not significantly affect blood lipid levels after 4 weeks or after 8 weeks compared to placebo (all p > 0.05). For oxLDL, blood pressure, glucose, and insulin levels and liver function parameters, also no statistically significant differences were found between the two intervention groups (all p > 0.05). Conclusions Blood lipid profiles were not significantly affected by 8 weeks OLE supplementation in overweight/obese subjects with mildly elevated cholesterol levels. Trial registered The trial has been registered at ClinicalTrials.gov (NCT02990637). Keywords Olive leaf extract · Overweight · Cardiovascular disease · Blood lipid profiles
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00394-020-02397-9) contains supplementary material, which is available to authorized users. * Yala Stevens [email protected] 1
Department of Internal Medicine, Division of Gastroenterology‑Hepatology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, P. O. Box 616, 6200 Maastricht, The Netherlands
2
BioActor BV, Maastricht, The Netherlands
3
Department of Methodology and Statistics, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands
The prevalence of overweight and obesity has increased rapidly over the last decades and poses a major public health concern, as excess body weight is associated with many health problems such as diabetes, liver disease, cardiovascular disease (CVD), and cancer [1, 2].
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