Olive leaf extract improves insulin sensitivity in overweight middle aged males; a randomized, double-blinded, placebo c
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ORAL PRESENTATION
Open Access
Olive leaf extract improves insulin sensitivity in overweight middle aged males; a randomized, double-blinded, placebo controlled, crossover trial Martin de Bock*, Jose Derraik, Christine Brennan, Eric Thorstensen, Wayne Cutfield†From 7th APPES Biennial Scientific Meeting Nusa Dua, Bali. 14-17 November 2012 Aim To investigate the impact of supplement olive leaf extract on insulin sensitivity in overweight middle aged males. Method We conducted a randomized, double-blinded, placebo controlled, crossover trial on an overweight middle aged male population at risk of developing the metabolic syndrome comparing olive leaf extract containing 51 mg oleuropein and 9.7 mg hydroxytyrosol to placebo. We measured insulin sensitivity (Matsuda method), pancreatic b-cell responsiveness (oral disposition index), lipid profile, ambulatory blood pressure, carotid intimal media thickness, body composition (DEXA) basal metabolic rate, hand-grip strength, wellness questionnaire, inflammatory cytokines, antioxidant potential all measured at baseline and end of both interventions. Results 38 participants were suitable for analysis. Even after controlling for total calorie intake fibre intake, physical activity, age, and percentage body fat (DEXA), insulin sensitivity was significant improved on treatment Vs placebo (19% p=
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