The effect of PD-1 expression on tumor-associated macrophage in T cell lymphoma
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RESEARCH ARTICLE
The effect of PD‑1 expression on tumor‑associated macrophage in T cell lymphoma J. Ruan1 · M. Ouyang1,2 · W. Zhang1 · Y. Luo3 · D. Zhou1 Received: 3 June 2020 / Accepted: 15 September 2020 © Federación de Sociedades Españolas de Oncología (FESEO) 2020
Abstract Purpose Our study aimed to explore the programmed death 1 (PD-1) expression on tumor-associated macrophage (TAM) in T cell non-Hodgkin lymphoma (T-NHL) and its relationship with lymphoma prognosis. The effect of PD-1 expression on the function of macrophages was also studied. Methods Multispectral image quantitative analysis was applied for detecting PD-1 expression on macrophages in T cell lymphoma tissues. The Kaplan–Meier analysis was performed to evaluate the value of PD-1 expression of TAM in predicting the overall survival of T-NHL. PD-1 overexpression THP-1-derived macrophage was constructed and was cocultured with Jurkat cells to explore the effect of PD-1 on macrophage function. Results In 17 T cell lymphoma cases, the 1-year overall survival rate was significantly lower in patients with higher PD-1 expression on TAMs (0.25 vs 0.86, p
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