Prognostic value of 25-hydroxy vitamin D in extranodal NK/T cell lymphoma
- PDF / 464,065 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 58 Downloads / 198 Views
ORIGINAL ARTICLE
Prognostic value of 25-hydroxy vitamin D in extranodal NK/T cell lymphoma Jin Mao 1,2,3 & Hua Yin 1,2,3 & Li Wang 1,2,3 & Jia-Zhu Wu 1,2,3 & Yi Xia 1,2,3 & Hua-Yuan Zhu 1,2,3 & Lei Fan 1,2,3 & Jian-Yong Li 1,2,3 & Jin-Hua Liang 1,2,3 & Wei Xu 1,2,3 Received: 29 July 2020 / Accepted: 26 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract 25-hydroxy vitamin D [25-(OH)D] is widely used to determine vitamin D status in clinic. The aim of our study was to evaluate the prognostic value of 25-(OH)D in extranodal NK/T cell lymphoma (ENKTL). Ninety-three (93) ENKTL patients with available serum 25-(OH)D values were enrolled in our study. Vitamin D deficiency is defined as a 25-(OH)D below 50 nmol/L (20 ng/ml). Univariate and multivariate regression analyses were performed to determine independent risk factors for progression-free survival (PFS) and overall survival (OS). Receiver operator characteristic (ROC) curves were plotted, and corresponding areas under the curves (AUC) were calculated to estimate the accuracy of PINK-E (prognostic index of natural killer lymphoma added with Epstein-Barr virus-DNA status) and 25-(OH)D deficiency in ENKTL risk-stratification. Our results suggested that the vitamin D deficiency was an independent inferior prognostic factor for both PFS [hazard ratio (HR), 2.869; 95% confidence interval (CI), 1.540 to 5.346; P = 0.003] and OS (HR, 3.204; 95% CI, 1.559 to 6.583; P = 0.006) in patients with ENKTL. Additionally, we demonstrated that adding 25-(OH)D deficiency to PINK-E score system indeed has a superior prognostic significance than PINK-E alone for PFS [AUC: 0.796 (95% CI: 0.699 to 0.872) vs. 0.759 (95% CI: 0.659 to 0.841), P = 0.020] and OS [AUC: 0.755 (95% CI: 0.655 to 0.838) vs. 0.721 (95% CI: 0.618 to 0.809), P = 0.040]. In conclusion, our study proved that 25-(OH)D deficiency was associated with inferior survival outcome of ENKTL patients. Keywords Extranodal NK/T cell lymphoma . 25-Hydroxy vitamin D . Prognostic index of natural killer cell lymphoma with Epstein-Barr virus - DNA status (PINK-E) . Prognosis
Introduction Extranodal natural killer/T-cell lymphoma (ENKTL) is a wellcharacterized subtype of mature T/NK-cell lymphoma. Asparaginase-based or pegaspargase-based chemotherapy Jin Mao and Hua Yin contributed equally to this work. * Jin-Hua Liang [email protected] * Wei Xu [email protected] 1
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China
2
Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, China
3
Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 210029, China
regimens or chemoradiation have been evaluated to improve response rates comparing with anthracycline-based regimens [1]. The latest prognostic index of natural killer lymphoma (PINK) added with Epstein-Barr virus (EBV)-DNA status (PINK-E) is a prognostic model based on non-anthracyclinebased chemotherapy, and it consists of fiv
Data Loading...
