The effects of topical treatment with curcumin on burn wound healing in rats
- PDF / 2,482,472 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 49 Downloads / 178 Views
ORIGINAL PAPER
The effects of topical treatment with curcumin on burn wound healing in rats Mustafa Kulac • Cevat Aktas • Feti Tulubas • Ramazan Uygur Mehmet Kanter • Mustafa Erboga • Mehmet Ceber • Birol Topcu • Oguz Aslan Ozen
•
Received: 22 July 2012 / Accepted: 19 September 2012 / Published online: 2 October 2012 Ó Springer Science+Business Media Dordrecht 2012
Abstract The present study was designed to determine the role of topical treatment with curcumin (Cur) on burn wound healing in rats. The Wistar-albino rats were randomly allotted into one of three experimental groups: 4th, 8th and 12th day (post burn) and all groups include subgroups which Burn and Burn ? Cur. Each group contains 12 animals. Burn wounds were made on the back of rat and Cur was administered topically. At the end of the study, all animals were sacrificed and the wound tissues removed for analyse to biochemical and histopathological changes. There was a significant increase in the hydroxyproline levels in the skin of the Cur groups. Cur treated wounds were found to heal much faster as indicated by improved rates of inflammatory cells, collagen deposition, angiogenesis, granulation tissue formation and epithelialization which were also confirmed by histopathological and biochemical examinations. Our data also indicate that there is a rise in the expression of
proliferating cell nuclear antigen in skin tissues of Curtreated rats in the Burn group. The results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing.
M. Kulac (&) Department of Dermatology, Faculty of Medicine, Namik Kemal University, 59030 Tekirdag, Turkey e-mail: [email protected]
M. Erboga Department of Histology and Embryology, Faculty of Medicine, University of Trakya, Edirne, Turkey
C. Aktas Department of Histology and Embryology, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
M. Ceber Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
F. Tulubas Department of Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
Keywords Burn wound healing Curcumin PCNA Hydroxyproline Rat
Introduction Thermal burn injuries are a major health care issue, and any therapeutic model that could benefit burn patients would benefit society in general (Shalom et al. 2011). Injury to skin initiates a cascade of events, including inflammation, proliferation, and remodeling (Chung and Kao 2009; Gong et al. 2010; Liang et al. 2011). The ideal wound dressing protects wound tissue from bacterial
B. Topcu Department of Biostatistics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey
R. Uygur O. A. Ozen Department of Anatomy, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey M. Kanter Department of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey
123
84
infection, reduces inflammation, and induces cell proliferation to aid in reconstruction of
Data Loading...
