The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population
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BioMed Central
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The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population Makiko Kishimoto1, Hiroshi Ujike*1,2, Yuko Okahisa1, Tatsuya Kotaka1, Manabu Takaki1, Masafumi Kodama1, Toshiya Inada2,3, Mitsuhiko Yamada2,4, Naohisa Uchimura2,5, Nakao Iwata2,6, Ichiro Sora2,7, Masaomi Iyo2,8, Norio Ozaki2,9 and Shigetoshi Kuroda1 Address: 1Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 2JGIDA (Japanese Genetics Initiative for Drug Abuse), Japan, 3Institute of Neuropsychiatry, Seiwa Hospital, Tokyo, Japan, 4Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan, 5Department of Neuropsychiatry, Kurume University Graduate School of Medicine, Kurume, Japan, 6Department of Psychiatry, Fujita Health University School of Medicine, Houmei, Japan, 7Department of Neuroscience, Division of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan, 8Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan and 9Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan Email: Makiko Kishimoto - [email protected]; Hiroshi Ujike* - [email protected]; Yuko Okahisa - [email protected]; Tatsuya Kotaka - [email protected]; Manabu Takaki - [email protected]; Masafumi Kodama - [email protected]; Toshiya Inada - [email protected]; Mitsuhiko Yamada - [email protected]; Naohisa Uchimura - [email protected]; Nakao Iwata - [email protected]; Ichiro Sora - [email protected]; Masaomi Iyo - [email protected]; Norio Ozaki - [email protected]; Shigetoshi Kuroda - [email protected] * Corresponding author
Published: 15 August 2008 Behavioral and Brain Functions 2008, 4:37
doi:10.1186/1744-9081-4-37
Received: 5 August 2008 Accepted: 15 August 2008
This article is available from: http://www.behavioralandbrainfunctions.com/content/4/1/37 © 2008 Kishimoto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Frizzled 3 (Fzd3) is a receptor required for the Wnt-signaling pathway, which has been implicated in the development of the central nervous system, including synaptogenesis and structural plasticity. We previously found a significant association between the FZD3 gene and susceptibility to schizophrenia, but subsequent studies showed inconsistent findings. To understand the roles of the FZD3 gene in psychotic disorders further, it should be useful to examine FZD3 in patients with methamphetamine psychosis because the clinical features of methamphetamine psychosis are similar to those of
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