The Genetics of Male Infertility
Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty
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THE GENETICS OF MALE INFERTILITY Edited by
DOUGLAS T. CARRELL, PhD Departments of Surgery (Urology), Obstetrics and Gynecology, and Physiology University of Utah School of Medicine Salt Lake City, UT
© 2007 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. All papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necesarily reflect the views of the publisher. This publication is printed on acid-free paper. f ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. Cover illustration: Fig. 1 from Chapter 5, “Physiological and Proteomic Approaches to Understanding Human Sperm Function: Prefertilization Events” by Sarah J. Conner, Linda Lefièvre, Jackson Kirkman-Brown, Gisela S. M. Machado-Oliveira, Frank Michelangeli, Stephen J. Publicover, and Christopher L. R. Barratt, Fig 3. from Chapter 7, “The Immunocytogenetics of Human Male Meiosis: A Progress Report” by Daniel Topping, Petrice Brown, and Terry Hassold, and Figs. 1 and 2 from Chapter 8, “The Clinical Relevance of Sperm Aneuploidy”, by Renee H. Martin. Production Editor: Jennifer Hackworth Cover design by Patricia F. Cleary For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: [email protected]; or visit our Website: www.humanapress.com Photocopy Authorization Policy: Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $30.00 per copy is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [1-58829-863-9/07 $30.00]. Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1 1-59745-176-2 (e-book) Library of Congress Cataloging-in-Publication Data The genetics of male infertility / edited by Douglas T. Carrell. p. ; cm. Includes bibliographical references and index. ISBN 1-58829-863-9 (alk. paper) 1. Infertility, Male--Genetic aspects--Congresses. 2. Spermatogenesis--Genetic aspects--Congresses. I. Carrell, Douglas T. [DNLM: 1. Infertility, Male--genetics--Congresses. 2. Genetic Techniques--Congresses. WJ 709 G3287 2007] RC889.G46 2007 616.6'921042--dc22
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PREFACE Male infertility is a common and severe health problem. Infertility not only affects one’s ability to have children, but also has emotional, psycho
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