The impact of homocysteine on the risk of coronary artery diseases in individuals with diabetes: a Mendelian randomizati
- PDF / 526,938 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 153 Views
ORIGINAL ARTICLE
The impact of homocysteine on the risk of coronary artery diseases in individuals with diabetes: a Mendelian randomization study Tian Xu1 · Songzan Chen1 · Fangkun Yang2 · Yao Wang1 · Kaijie Zhang1 · Guosheng Fu1 · Wenbin Zhang1 Received: 15 July 2020 / Accepted: 18 September 2020 © The Author(s) 2020
Abstract Aims Observational studies have reported that homocysteine (Hcy) is associated with an increased risk of coronary artery disease (CAD) in individuals with diabetes, though controversy remains. The present study aimed to investigate the causal association between Hcy and CAD in individuals with diabetes. Methods A 2-sample Mendelian randomization (MR) study was designed to infer causality. Genetic summary data on the association of single nucleotide polymorphisms (SNPs) with Hcy were extracted from the hitherto largest genome-wide association study (GWAS) of up to 44,147 individuals of European ancestry. SNP-CAD data were obtained from another recently published GWAS which included 15,666 individuals with diabetes (3,968 CAD cases, 11,696 controls). The fixed-effects inverse variance-weighted method was employed to calculate the effect estimates. Other robust methods and leave-one-out analyses were used in the follow-up sensitivity analyses. Potential pleiotropy was assessed with the MR-Egger intercept test. Results The 2-sample MR analysis suggested no evidence of an association between genetically predicted plasma Hcy levels and CAD risk in individuals with diabetes (odds ratio = 1.14, 95% confidence interval: 0.82–1.58, p = 0.43) using 9 SNPs as instrumental variables. Similar results were observed in the follow-up sensitivity analyses. The MR-Egger intercept test indicated no evidence of directional pleiotropy (intercept = 0.03, 95% confidence interval: − 0.08–0.03, p = 0.35). Conclusion This 2-sample MR analysis found no evidence of a causal association between plasma Hcy levels and CAD risk in individuals with diabetes. Keywords Plasma homocysteine levels · Coronary artery disease · Diabetes · Mendelian randomization · Causal association
Introduction
Managed by Massimo Porta. Tian Xu and Songzan Chen have contributed equally to this work * Guosheng Fu [email protected] * Wenbin Zhang [email protected] 1
Key Laboratory of Biotherapy of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, People’s Republic of China
Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, People’s Republic of China
2
Coronary artery disease (CAD) remains the leading cause of death worldwide [1–3]. Despite advances in medical and interventional treatment modalities, outcomes are still unsatisfactory in high-risk subsets of patients [4] and particularly in patients with diabetes. Coronary artery disease is a major prognostic determinant for patients with diabetes as cardiovascular death is responsible for more than 50% o
Data Loading...
