The influence of mild cataract on ISCEV standard electroretinogram recorded from mydriatic eyes
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ORIGINAL RESEARCH ARTICLE
The influence of mild cataract on ISCEV standard electroretinogram recorded from mydriatic eyes Atsuhiro Tanikawa . Keita Suzuki . Ryoko Nomura . Hidenori Tanaka . Tadashi Mizuguchi . Yoshiaki Shimada . Masayuki Horiguchi
Received: 4 March 2020 / Accepted: 26 August 2020 Ó Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To investigate the effect of mild cataract and its surgery on the ISCEV standard electroretinogram (ERG) by comparing pre- and postoperative ERGs elicited from fully dilated eyes. Methods Twenty-two patients participated. Each eye had cataract of grade 2 according to Emery-Little classification. None had complications during and after phacoemulsification and intraocular lens implantation. According to the ISCEV standard, pre- and 1-week postoperative full-field ERGs, dark adapted (DA) 0.01, DA 3, DA 3 oscillatory potentials (OPs), DA 10, and light adapted (LA) 3, and LA 3 flicker, were elicited from fully dilated eyes using skin electrodes. Photopic negative response (PhNR) 1 amplitude was measured from the baseline to the trough before the i-wave in the LA 3 ERG waveform. Statistical analysis was performed using SigmaPlot version 11.0 (Systat Software, Inc., San Jose, CA, USA). Pre- and postoperative data were compared using a paired t-test. Non-normally distributed data were evaluated using the Wilcoxon signed rank test. Results The pre- and 1-week postoperative amplitudes in each component were as follows: DA 0.01: 48.4 ± 19.5 lV and 57.1 ± 20.0 lV (p = 0.002),
a-wave of DA3: 51.5 ± 14.8 lV and 58.3 ± 17.3 lV (p = 0.003), b-wave of DA3: 88.3 ± 27.5 lV and 101.5 ± 29.7 lV (p = 0.003), DA 3 ROPs (sum of DA 3 OP1, OP2, and OP3 amplitude): 30.7 ± 16.3 lV and 37.1 ± 21.9 lV (p \ 0.001), a-wave of DA 10: 65.5 ± 18.8 lV and 74.2 ± 19.5 lV (p \ 0.001), b-wave of DA 10: 95.5 ± 29.6 lV and 111.1 ± 29.9 lV (p \ 0.001), a-wave of LA 3: 7.2 ± 2.6 lV and 8.2 ± 2.2 lV (p = 0.025), b-wave of LA 3: 30.6 ± 12.9 lV and 35.3 ± 12.7 lV (p = 0.003), PhNR1: 5.8 ± 2.5 lV and 5.5 ± 2.6 lV (p = 0.562), and LA 3 flicker: 25.4 ± 8.9 lV and 27.8 ± 8.6 lV (p = 0.039), respectively. The implicit time of all the components did not reveal significant differences before and after surgery. Conclusions Cataractous lens removal and intraocular lens implantation may influence ISCEV standard ERGs, even if the cataract is relatively mild. Keywords ERG Skin electrodes Mild cataract IOL Mydriasis
Introduction A. Tanikawa (&) K. Suzuki R. Nomura H. Tanaka T. Mizuguchi Y. Shimada M. Horiguchi Department of Ophthalmology, Fujita Health University School of Medicine, Toyoake, Japan e-mail: [email protected]
The full-field electroretinogram (ERG) is a valuable examination tool for evaluating retinal function. However, the results may be affected by opacity of the ocular media, including corneal opacity, cataract,
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or vitreous hemorrhage [1–5]. In eyes with dense or mature cataract, several inv
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