The influence of parathyroidectomy on cardiometabolic risk factors in patients with primary hyperparathyroidism: a syste
- PDF / 955,705 Bytes
- 14 Pages / 595.276 x 790.866 pts Page_size
- 41 Downloads / 199 Views
META-ANALYSIS
The influence of parathyroidectomy on cardiometabolic risk factors in patients with primary hyperparathyroidism: a systematic review and meta-analysis Maryam Yavari1 Awat Feizi2 Fahimeh Haghighatdoost3 Azin Ghaffari4 Hassan Rezvanian1 ●
●
●
●
1234567890();,:
1234567890();,:
Received: 10 August 2020 / Accepted: 2 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Primary hyperparathyroidism (PHPT) is associated with increased risk of cardiovascular morbidity and mortality. We aim to determine whether parathyroidectomy (PTX) can change cardiometabolic risk factors including serum lipids, glycemic parameters, systolic and diastolic blood pressure, C reactive protein (CRP), and body mass index (BMI). Methods MEDLINE, Web of Science, Scopus, and Google Scholar were searched for relevant articles published till June 2020. Fixed-effect or random-effects models were used to estimate the weighted mean difference (WMD) and 95% CI for outcomes where applicable. Results In total, 34 studies were eligible to be included in the current meta-analysis. Our results indicated no favorable change in serum triglyceride (n = 13, WMD = −0.06, 95% CI: −0.15, 0.03 mmol/L), total cholesterol (n = 15, WMD = 0.01, 95% CI: −0.14, 0.16 mmol/L), LDL-C (n = 10, WMD = −0.01, 95% CI: −0.17, 0.19 mmol/L), HDL-C (n = 10, WMD = 0.03, 95% CI: −0.001, 0.06 mmol/L), and CRP (n = 5, WMD = 0.82, 95% CI: −0.01, 1.64 mg/L) after PTX in PHPT patients. However, glucose (n = 24, WMD = −0.16, 95% CI: −0.26, −0.06 mmol/L), serum insulin (n = 12, WMD = −1.11, 95% CI: −1.73, −0.49 µIU/mL), systolic (n = 17, WMD = −10.14, 95% CI: −12.27, −8.01 mmHg), and diastolic (n = 16, WMD = −5.21, 95% CI: −7.0, −3.43 mmHg) blood pressures were decreased after PTX, whilst a significant increase was observed in BMI (n = 13, WMD = 0.35, 95% CI: 0.19, 0.51 kg/m2). Conclusions PTX could improve glycemic parameters and blood pressure, without any significant change in serum lipoproteins and CRP. Keywords Parathyroidectomy Primary hyperparathyroidism Cardiometabolic risk Dyslipidemia Blood pressure Glycemic response ●
●
●
●
●
Introduction Supplementary information The online version of this article (https:// doi.org/10.1007/s12020-020-02519-7) contains supplementary material, which is available to authorized users. * Hassan Rezvanian [email protected] 1
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2
Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
3
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
4
Department of Nephrology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran
Primary hyperparathyroidism (PHPT) is a common endocrine disease which predominantly characterized by elevated serum calcium levels and unsuitable increase in parathyroid hormone (PTH) [1]. It is estimat
Data Loading...
