The Level of Circulating Microparticles in Patients with Coronary Heart Disease: a Systematic Review and Meta-Analysis
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REVIEW
The Level of Circulating Microparticles in Patients with Coronary Heart Disease: a Systematic Review and Meta-Analysis Baofu Wang 1 & Tong Li 1 & Xiaowan Han 1 & Yang Li 1 & Wenkun Cheng 1 & Lei Wang 1 & Ziwen Lu 1 & Jingjing Yang 1 & Mingjing Zhao 1 Received: 11 October 2019 / Accepted: 29 November 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Background/Aims To assess the correlation between microparticles (MPs) and subgroups of coronary heart disease (CHD), including stable angina (SA), unstable angina (UA), and myocardial infarction (MI). Methods A literature search was carried out systematically to identify available case–control studies. The level of MPs was compared and MPs’ merged standardized mean differences (SMDs) were pooled for the meta-analysis. Results Six studies met the inclusion criteria and were used for systematic review and meta-analysis. The level of MPs was higher in patients with CHD than that in the NS (normal subjects) group (SMD 2.28; 95% confidence interval (CI) 1.70–2.85; P = 0.000), and was also significantly different in subgroups of CHD (UA vs SA: SMD 2.35, 95% CI 1.56–3.14, P = 0.000; MI vs SA: SMD 3.08, 95% CI 2.07–4.09, P = 0.000; MI vs UA: SMD 0.83, 95% CI 0.41–1.26, P = 0.000). The similar results were also found in subgroups analyses of CD31+CD42− endothelium-derived microparticles (EMPs) and CD144+EMPs. Conclusion The level of MPs, especially CD31+CD42−EMPs and CD144+EMPs, had an increasing trend with the degree of CHD: NS
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