The Lubricating Function of Mucin at the Gastroscope Device-Esophagus Interface
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ORIGINAL PAPER
The Lubricating Function of Mucin at the Gastroscope Device‑Esophagus Interface Chengxiong Lin1 · Wei Liu1 · Jingyang Xie1 · Wei Li1 · Zhongrong Zhou1 Received: 7 March 2020 / Accepted: 10 June 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The mucous layer on the surface of human digestive tract is a dynamically balanced protective system, mainly containing mucin, enzymes, bicarbonate, epidermal growth factor and other protective factors. It has been found that mucins can protect epithelial cells from infection, dehydration, and physical, mechanical or chemical damage. There are a variety of disturbances that affect or destroy the function of the mucous layer, including mucus dysfunction and diseases of digestive tract. In this paper, the mechanical function of mucin on the surface of esophagus was studied using the UMT Tribometer with the porcine esophagus as the experiment sample. Trypsin was used to control the mucin content on the surface of esophagus. Results showed that the trypsin can affect the function of the mucin on the surface of esophagus. The friction coefficient and the relevant energy dissipation of trypsin-treated and non-trypsin-treated samples were significantly different. Due to the reduction of mucin on the esophageal surface by trypsin treatment, the friction coefficient and energy dissipation of the esophageal surface were significantly higher than that of the samples without trypsin treatment. During the friction test, the esophagus surface was severely damaged at both macro and micro scales after trypsin treatment, which indicated that the mucin can play a lubrication role at the gastroscope device-esophagus interface. The results can provide reference for clinical endoscopic examination and medical advice for clinical practice. Keywords Mucin · Trypsin · Esophagus · Frictional behavior
1 Introduction The mucous layer on the surface of human digestive tract is a dynamic and balanced protective system, which mainly contains mucin, enzyme, bicarbonate, epidermal growth factor, transforming growth factor and other protective factors [1, 2]. As the main and most protective component of the mucous layer, mucins belong to the protective glycoproteins, which are characterized by dense O-linked glycosylation and tandem repeat domains, and are fairly resistant to the action of proteases [3]. Human mucins are mainly found in the digestive tract, respiratory tract, reproductive tract, eyes and mouth. It can be secreted by epithelial goblet cells and Chengxiong Lin and Wei Liu: co-first author * Wei Li [email protected] 1
Tribology Research Institute, Key Laboratory for Advanced Technology of Materials of Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China
submucosal glands in the digestive tract. Besides, the mucin mainly consists of two types: secreted mucin and membranebound mucin. The former is characterized by high molecular weight and size, a high proportion of O-glycosidically linked carbohydrate and
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