The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database
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ORIGINAL ARTICLE
The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database Hsiang‑Ying Lee1,2 · Jia‑Hong Tang3 · Yen‑Hsu Chen2,4,5 · Wen‑Jeng Wu6 · Yung‑Shun Juan2 · Wei‑Ming Li7 · Ta‑Chien Chan8,9 Received: 15 July 2020 / Accepted: 4 November 2020 © Japan Society of Clinical Oncology 2020
Abstract Purpose The metabolic syndrome was associated with bladder cancer in the previous studies. However, there have no largescale cohort studies to elucidate the relationship between metabolic syndromes and urothelial carcinoma including urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC). Methods We analyze a population-based cohort study by using physical examination data and diagnosis of UC from the Taiwan Cancer Registry Database. Differences in demographic and clinical characteristics among UTUC and non-UTUC groups, UBUC and non-UBUC groups were compared. Odds ratios (ORs) for determining risk factors were estimated through the multiple logistic regression model. Results A total of 557,063 records for 211,319 participants which consisted of 31 UTUC and 309 UBUC met the eligibility criteria in this study. Our results showed that female are more likely to develop UTUC than male. As opposed to UTUC, male are more likely to develop UBUC than female. It also showed that participants smoked or chewed betel quid daily are more likely to develop UBUC. Age and estimated glomerular filtration rate (eGFR) are significantly increased the risk of developing UTUC. The association between the eGFR and risk of UTUC is stronger (P
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