The Molecular Basis of Human Cancer
This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These
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The Molecular Basis of Human Cancer Second Edition
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The Molecular Basis of Human Cancer
William B. Coleman • Gregory J. Tsongalis Editors
The Molecular Basis of Human Cancer
Editors William B. Coleman Department of Pathology and Laboratory Medicine Curriculum in Toxicology UNC Program in Translational Medicine UNC Lineberger Comprehensive Center University of North Carolina School of Medicine Chapel Hill, NC, USA
Gregory J. Tsongalis Laboratory for Clinical Genomics and Advanced Technology (CGAT) Department of Pathology and Laboratory Medicine Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center Lebanon, NH, USA Geisel School of Medicine at Dartmouth Hanover, NH, USA
ISBN 978-1-934115-18-3 ISBN 978-1-59745-458-2 DOI 10.1007/978-1-59745-458-2
(eBook)
Library of Congress Control Number: 2016953141 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
The information contained in this textbook describes the ever-expanding field of cancer biology and our contemporary understanding of the pathology, pathogenesis, and pathophysiology of the diverse collection of diseases representing human cancer. Hence, this work represents the culmination of innumerable small successes that emerged from the ceaseless pursuit of new knowledge by countless clinical, experimental, and translational cancer biologists working around the world on all aspects of human cancer. Their ingenuity and hard work have dramatically advanced the field of cancer pathobiology over time, and particularly during the last 25 years. This book is a tribute to the dedication, diligence, and perseverance of individual scientists who contributed to the advancement of our understanding of the molecular basis of human cancer, especiall
