The Myc/Max/Mad Transcription Factor Network
Intense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California · H. Wagner, Munich
R.N. Eisenman (Ed.)
The Myc/Max/Mad Transcription Factor Network With 28 Figures and 3 Tables
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Robert N. Eisenman, Prof. Dr., Ph.D. Division of Basic Sciences Fred Hutchinson Cancer Research Center P.O. Box 19024 Seattle, Washington 98108-1024 USA e-mail: [email protected] Cover Illustration: The cover figure depicts a Myc-Max protein heterodimer interacting with its CACGTG binding site in DNA, superimposed over an image of DAPI-stained cell nuclei. The large cell nuclei are located within a Drosophila larval salivary gland ectopically expressing Drosophila Myc (dMyc) while the small nuclei are from fat body cells lacking ectopic dMyc (from Pierce SB, Yost C, Britton JS, Loo LW, Flynn EM, Edgar BA, Eisenman RN (2004) dMyc is required for larval growth and endoreplication in Drosophila. Development 131: 2317-2327). See chapter by Nair and Burley, within, for review of structural studies on Myc-Max dimers.
Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN-10 3-540-23968-5 Springer Berlin Heidelberg New York ISBN-13 978-3-540-23968-0 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Simon Rallison, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Nadja Kroke, Leipzig Cover design: design & production GmbH, Heidelberg Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper SPIN 11001973 27/3150/YL – 5 4 3 2 1 0
Preface
Scientists often look askance at their colleagues whose research appears too strongly focused on a single gene or gene product. We are supposed to be inter
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