The Nociceptin/Orphanin FQ Peptide Receptor
The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-target
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Mei-Chuan Ko Girolamo Caló Editors
The Nociceptin/ Orphanin FQ Peptide Receptor
Handbook of Experimental Pharmacology
Volume 254 Editor-in-Chief James E. Barrett, Philadelphia
Editorial Board Veit Flockerzi, Homburg Michael A. Frohman, Stony Brook Pierangelo Geppetti, Florence Franz B. Hofmann, München Martin C. Michel, Mainz Clive P. Page, London Walter Rosenthal, Jena KeWei Wang, Qingdao
The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unrivalled reference source. HEP is indexed in PubMed and Scopus.
More information about this series at http://www.springer.com/series/164
Mei-Chuan Ko • Girolamo Caló Editors
The Nociceptin/ Orphanin FQ Peptide Receptor
Editors Mei-Chuan Ko Department of Physiology and Pharmacology Wake Forest University, School of Medicine Winston-Salem, NC, USA
Girolamo Caló Department of Medical Sciences, Section of Pharmacology University of Ferrara Ferrara, Italy
ISSN 0171-2004 ISSN 1865-0325 (electronic) Handbook of Experimental Pharmacology ISBN 978-3-030-20185-2 ISBN 978-3-030-20186-9 (eBook) https://doi.org/10.1007/978-3-030-20186-9 # Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
In memory of Professor Domenico Regoli, an outstanding scientist and a great friend
Preface
Since 1994, when the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor (aka, opioid receptor like 1
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