The old CEACAMs find their new role in tumor immunotherapy
- PDF / 803,894 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 52 Downloads / 190 Views
REVIEW
The old CEACAMs find their new role in tumor immunotherapy Zi-Wen Han 1,2 & Zhi-Wu Lyv 3 & Bin Cui 3 & Ying-Ying Wang 1,2 & Jun-Ting Cheng 1,2 & Ying Zhang 1,2 & Wen-Qi Cai 1,2 & Yang Zhou 1,2 & Zhao-Wu Ma 1,2 & Xian-Wang Wang 1,2,4 & Xiao-Chun Peng 1,2,5 & Shu-Zhong Cui 6 & Ying Xiang 1,2 & Mo Yang 7 & Hong-Wu Xin 1,2 Received: 28 December 2019 / Accepted: 21 May 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Summary Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) contain 12 family members(CEACAM1、CEACAM3、CEACAM4、CEACAM5、CEACAM6、CEACAM7、CEACAM8、CEACAM16、CEACAM18、CEACAM19、CEACAM20 and CEACAM21)and are expressed diversely in different normal and tumor tissues. CEA (CEACAM5) has been used as a tumor biomarker since 1965. Here we review the latest research and development of the structures, expression, and function of CEACAMs in normal and tumor tissues, and their application in the tumor diagnosis, prognosis, and treatment. We focus on recent clinical studies of CEA targeted cancer immunotherapies, including bispecific antibody (BsAb) for radio-immuno-therapy and imaging, bispecific T cell engager (BiTE) and chimeric antigen receptor T cells (CAR-T). We summarize the promising clinical relevance and challenges of these approaches and give perspective view for future research. This review has important implications in understanding the diversified biology of CEACAMs in normal and tumor tissues, and their new role in tumor immunotherapy. Keywords Carcinoembryonic Antigen-related Cell Adhesion Molecules (CEACAMs) . Bispecific Antibody(BsAb) . Bispecific T cell engager (BiTE) . Chimeric Antigen Receptor T cell (CAR-T) . Tumor immunotherapy
Abbreviations BiTE Bispecific T Cell Engager. BsAb Bispecific Antibody. CEA Carcinoembryonic Antigen. CEACAM Carcinoembryonic Antigen-Related Cell Adhesion Molecule.
CAR-T HSG Ig TAA HAI SIRT
Chimeric Antigen Receptor T Cell. Histamine-succinylglycine. Immunoglobulin. Tumor-associated antigens. Hepatic Intraarterial Infusion. Selective Internal Radiation Therapy.
Zi-Wen Han, Zhi-Wu Lyv and Bin Cui contributed equally to this work. * Ying Xiang [email protected]
3
Department of Pathology, Lianjiang People’s Hospital, Zhanjiang, Guangdong 524400, China
* Mo Yang [email protected]
4
Department of Laboratory Medicine, School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China
5
Department of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei 434023, China
* Hong-Wu Xin [email protected] 1
Laboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China
6
State Key Laboratory of Respiratory Disease, Affiliated Cancer Hospital Institute of Guangzhou Medical University, Guangzhou 510095, China
2
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Health Science Center, Yangtze University, J
Data Loading...
