Advances in Tumor Immunology and Immunotherapy
This volume explores recent advances in understanding of fundamental immunology and insights into the dynamic interactions between tumors and the immune system, that provide new opportunities for therapeutic intervention in c
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Joseph D. Rosenblatt Eckhard R. Podack Glen N. Barber Augusto Ochoa Editors
Advances in Tumor Immunology and Immunotherapy
Current Cancer Research
Series Editor Wafik El-Deiry
For further volumes: http://www.springer.com/series/7892
Joseph D. Rosenblatt • Eckhard R. Podack Glen N. Barber • Augusto Ochoa Editors
Advances in Tumor Immunology and Immunotherapy
Editors Joseph D. Rosenblatt Sylvester Comprehensive Cancer Center (SCCC) School of Medicine University of Miami Miami, FL, USA Glen N. Barber Sylvester Comprehensive Cancer Center University of Miami Miami, FL, USA
Eckhard R. Podack Department of Microbiology and Immunology University of Miami Miami, FL, USA Augusto Ochoa Department of Pediatrics Louisiana State University Health Sciences Center New Orleans, LA, USA
ISBN 978-1-4614-8808-8 ISBN 978-1-4614-8809-5 (eBook) DOI 10.1007/978-1-4614-8809-5 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013951429 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Part I
Immune Activation, Suppression and Manipulation of the Immune Antitumor Response
Myeloid-Derived Suppressor Cells in Cancer .............................................. Christos E. Kyriakopoulos, A
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