The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways
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POSTER PRESENTATION
Open Access
The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways Nicolas Glaichenhaus1,2*, Valérie Julia1,2 From 6th European Workshop on Immune-Mediated Inflammatory Diseases Nice, France. 23-25 November 2011 Background The prevalence of asthma has steadily increased during the last decade, probably as the result of changes in the environment, including reduced microbial exposure during infancy. Accordingly, experimental studies have shown that deliberate infections with live pathogens prevent the development of allergic airway diseases in mice. Bacterial extracts are currently used in children suffering from repeated upper respiratory tract infections. In this study, we have investigated whether bacterial extracts, commercially available as Broncho-Vaxom (BV), could prevent allergic airway disease in mice.
Published: 23 November 2011
doi:10.1186/1479-5876-9-S2-P22 Cite this article as: Glaichenhaus and Julia: The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Journal of Translational Medicine 2011 9(Suppl 2):P22.
Results Oral treatment with BV suppressed airway inflammation through IL-10-dependent and MyD88-dependent mechanisms and induced the conversion of FoxP3-negative T cells into FoxP3-positive regulatory T cells. Furthermore, CD4positive T cells purified from the trachea of BV-treated mice conferred protection against airway inflammation when adoptively transferred into sensitized mice. Conclusion Treatment with BV could possibly be a safe and efficient strategy to prevent the development of allergic disease in children.
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Author details 1 Université de Nice-Sophia Antipolis, Institut National de la Santé et de la Recherche Médicale, Valbonne, France. 2Université de Lille 2, Institut National de la Santé et de la Recherche Médicale, Lille, France.
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1 Université de Nice-Sophia Antipolis, Institut National de la Santé et de la Recherche Médicale, Valbonne, France Full list of author information is available at the end of the article
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© 2011 Glaichenhaus and Julia; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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