The Orexin/Hypocretin System Physiology and Pathophysiology
Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocre
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ontemporary linical euroscience
Series Editors: Ralph Lydic and Helen A. Baghdoyan
Transgenic and Knockout Models of Neuropsychiatric Disorders, edited by Gene S. Fisch and Jonathan Flint, 2006 The Orexin/Hypocretin System: Physiology and Pathophysiology, edited by Seiji Nishino and Takeshi Sakurai, 2006 The G Protein-Coupled Receptors Handbook, edited by Lakshmi A. Devi, 2005 Attention Deficit Hyperactivity Disorder: From Genes to Patients, edited by David Gozal and Dennis L. Molfese, 2005 Genetics and Genomics of Neurobehavioral Disorders, edited by Gene S. Fisch, 2003 Sedation and Analgesia for Diagnostic and Therapeutic Procedures, edited by Shobha Malviya, Norah N. Naughton, and Kevin K. Tremper, 2003 Neural Mechanisms of Anesthesia, edited by Joseph F. Antognini, Earl E. Carstens, and Douglas E. Raines, 2002 Glutamate and Addiction, edited by Barbara Herman, 2002 Molecular Mechanisms of Neurodegenerative Diseases, edited by Marie-Françoise Chesselet, 2000
Contemporary Clinical Neuroscience
THE OREXIN/HYPOCRETIN SYSTEM Physiology and Pathophysiology Edited by
SEIJI NISHINO,
MD, P hD
Center for Narcolepsy Stanford University School of Medicine Stanford, CA
and
TAKESHI SAKURAI,
MD , P hD
Department of Pharmacology Institute of Basic Medical Sciences University of Tsukuba, Ibaraki, Japan
© 2006 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. All authored papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents. Cover illustration: Figure 7 from Chapter 21, “Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy,” by Takashi Kanbayashi, Junko Arii, Hideaki Kondo, Testuo Shimizu, and Seiji Nishino. Cover design by Patricia F. Cleary. For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: [email protected] or visit our website at www.humanapress.com The opinions expressed herein are the views of the authors and may not necessarily reflect the official policy of the National Institute on Drug Abuse or any other parts of the US Department of Health and Human Services. The US Government does not endorse or favor an
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