Arterial Chemoreceptors in Physiology and Pathophysiology

Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus

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Chris Peers Prem Kumar Christopher N. Wyatt Estelle Gauda Colin A. Nurse Nanduri Prabhakar Editors

Arterial Chemoreceptors in Physiology and Pathophysiology

Advances in Experimental Medicine and Biology Volume 860 Editorial board: Irun R. Cohen, The Weizmann Institute of Science, Rehovot, Israel N. S. Abel Lajtha, Kline Institute for Psychiatric Research, Orangeburg, NY, USA John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Rodolfo Paoletti, University of Milan, Milan, Italy

More information about this series at http://www.springer.com/series/5584

Chris Peers • Prem Kumar Christopher N. Wyatt • Estelle Gauda Colin A. Nurse • Nanduri Prabhakar Editors

Arterial Chemoreceptors in Physiology and Pathophysiology

Editors Chris Peers Leeds Institute of Cardiovascular and Metabolic Medicine Faculty of Medicine and Health University of Leeds Leeds, UK Christopher N. Wyatt Department of Neuroscience Cell Biology and Physiology Wright State University Dayton, OH, USA Colin A. Nurse Department of Biology McMaster University Hamilton, ON, Canada

Prem Kumar College of Medical and Dental Sciences University of Birmingham Birmingham, UK Estelle Gauda Department of Pediatrics Johns Hopkins Medical Institutions Baltimore, MD, USA Nanduri Prabhakar Institute for Integrative Physiology and Center for Systems Biology of O(2) Sensing Biological Sciences Division University of Chicago Chicago, IL, USA

ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-18439-5 ISBN 978-3-319-18440-1 (eBook) DOI 10.1007/978-3-319-18440-1 Library of Congress Control Number: 2015947563 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

Preface

This volume of Advances in Experimental Medicine and Biol