The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis
Rheumatoid arthritis as a common autoimmune inflammatory disorder with unknown etiology can affect 0.5–1% of adults in developed countries. It involves more than just the patient’s joints and can be accompanied by several comorbidities and affect cardiova
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The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis Peyvand Parhizkar Roudsari, Sepideh Alavi-Moghadam, Mostafa Rezaei-Tavirani , Parisa Goodarzi , Akram Tayanloo-Beik , Forough Azam Sayahpour, Bagher Larijani , and Babak Arjmand
Abstract
Rheumatoid arthritis as a common autoimmune inflammatory disorder with unknown etiology can affect 0.5–1% of adults in developed countries. It involves more than just the patient’s joints and can be accompanied by several comorbidities and affect cardiovascular, pulmonary, and some other systems of the human body. P. P. Roudsari and A. Tayanloo-Beik Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]; a. [email protected] S. Alavi-Moghadam Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]
Although cytokine-mediated pathways are mentioned to have a central role in RA pathogenesis, adaptive and innate immune systems and intracellular signaling pathways all have important roles in this process. Non-steroidal anti-inflammatory drugs, glucocorticoids, conventional disease-modifying anti-rheumatic drugs, and biological agents are some mentioned
F. A. Sayahpour Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran e-mail: [email protected] B. Larijani Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical sciences, Tehran, Iran e-mail: [email protected]
M. Rezaei-Tavirani Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran e-mail: [email protected]
B. Arjmand (*) Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
P. Goodarzi Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]
P. P. Roudsari et al.
medications used for RA. They are accompanied by some adverse effects and treatment failures which elucidates the needing for novel and more powerful therapeutic approaches. Stem cellbased therapies and their beneficial effects on therapeutic processes of different diseases have been founded so far. They can be an alternative and promising therapeutic approach for RA, too; due to their effects on immune responses of the disease. This review, besides some explanations about RA characteristics, addresses the outcome of the stem
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