The Prevalence and Clinical Characteristics of Essential Tremor in Elderly Chineses: A Population-Based Study
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THE PREVALENCE AND CLINICAL CHARACTERISTICS OF ESSENTIAL TREMOR IN ELDERLY CHINESES: A POPULATION-BASED STUDY H. SUN1,2,3,4, F. SUN5, X.-Q. ZHANG3, X.-H. FANG6, P. CHAN1,2,3,4,7 1. National clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, China; 2. Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China; 3. Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China; 4. Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China; 5. Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing, China; 6. Department of Evidence Based Medicine, Xuanwu Hospital of Capital Medical University, Beijing, China; 7. Parkinson Disease Center of Beijing Institute for Brain Disorders and Beijing Key Laboratory on Parkinson’s disease, Beijing, China. Corresponding author: Piu Chan, MD PhD, Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China, Tel: +86-10-83198677, Fax: +86-10-83161294, Email: [email protected]
Abstract: Objectives: To investigate the prevalence and the clinical feature of essential tremor (ET) in a community cohort in Beijing. Methods: Using a door-to-door, two-phase approach, we investigated 2,835 residents aged ≥55 years old from rural, urban, and mountain areas. Results: The prevalence rate of ET was 4.29%, 2.85%, and 2.29% in rural, urban, and mountain areas, respectively. The overall age- and sex-adjusted prevalence was 3.29%. Among those aged ≥75 years, the prevalence rate in the urban area was higher than those in the rural and mountain areas. The prevalence rate increased with age, and the prevalence was higher among men (6.0%) than among women (3.6%). There was a correlation of ET prevalence with age, sex, and habitation area, but not with alcohol, tea drinking, and occupation. Women (25%) with ET were more likely to have head tremor than men (16.9%). Conclusions: The ET prevalence in the elderly of Beijing was 3.29% which is higher in the urban area and in men. Key words: essential tremor, epidemiology, prevalence, population-based, gender.
Introduction
distribution, age, economic, and education levels were similar to the population from Beijing. Three districts of Xuanwu, Daxing, and Huairou were randomly selected. Xuanwu is a central urban area, Daxing is a rural area, and Huairou is a mountainous area. The baseline population was 3,257 in 1992. In order to maintain a stable size of the cohort, 1,022 subjects randomly selected from the same districts were added in 1994 while another 500 younger subjects between 55 and 60 years old were joined in 2000. All the population was selected with the same principle as 1992. As shown in Figure 1, 2,835 subjects were interviewed for ET, parkinsonism, and dementia in 2000.
Essential tremor (ET) is considered the most prevalent adult movement disorder and is regarded as one of the most common adult neurological disorders
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