The prognostic significance of whole-body and spleen MTV (metabolic tumor volume) scanning for patients with diffuse lar
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ORIGINAL ARTICLE
The prognostic significance of whole‑body and spleen MTV (metabolic tumor volume) scanning for patients with diffuse large B cell lymphoma Shintaro Yamanaka1 · Masao Miyagawa2 · Yoshifumi Sugawara3 · Shinji Hasebe4 · Tomomi Fujii4,5 · Kazuto Takeuchi4 · Keiko Tanaka6,7 · Yoshihiro Yakushijin4,5 Received: 11 July 2020 / Accepted: 28 September 2020 © Japan Society of Clinical Oncology 2020
Abstract Background Positron Emission Tomography-Computed Tomography (PET-CT) has been changing diagnostic and therapeutic strategies for patients with cancers, and several PET-CT-related prognostic factors have been reported. We have focused on metabolic tumor volumes (MTVs) over the whole body and in specific organs using 18F-PET-CT imaging, and have compared clinical data to know the prognosis of patients with diffuse large B cell lymphoma (DLBCL). Patients and methods From January 2006 to December 2016, patients who were newly diagnosed for de novo DLBCL and who received 18F-FDG PET-CT scans for disease staging at Ehime University Hospital were reviewed. Results A total of forty out of 108 patients with DLBCL were analyzed. The median and the average follow-up were 3.9 years and 3.6 years. Both MTV50 and MTV60 whole-body searching indicated effective prognostic values for patients with DLBCL statistically (P = 0.027). However, analysis of MTVs in the spleen and in bone marrow did not provide any prognostic value. Receiver operating characteristic (ROC) analysis indicated that the cutoff level 25.8 in MTV60 is the most effective prognostic value (P = 0.022) which predicts patient survival after treatment with R-CHOP chemotherapy. Conclusion MTV60 using whole-body scanning appears to be an effective indicator in DLBCL and indicates the patient prognosis. Keywords SUV · MTV · 18F-FDG-PET · Diffuse large B cell lymphoma
Introduction * Yoshihiro Yakushijin [email protected]‑u.ac.jp 1
Ehime University School of Medicine, Toon, Ehime, Japan
2
Department of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
3
Department of Diagnostic Radiology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan
4
Cancer Center, Ehime University Hospital, Toon, Ehime, Japan
5
Department of Clinical Oncology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791‑0295, Japan
6
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
7
Research Promotion Unit, Translation Research Center, Ehime University Hospital, Toon, Ehime, Japan
Positron Emission Tomography-Computed Tomography (PET-CT) is the most advanced medical imaging technique available recently, and has dramatically changed not only cancer diagnosis but also treatment strategies for patients with cancers. Recent clinical studies have reported that various types of data derived from PET-CT analysis may influence the prognosis for cancer patients directly or indirectly. Several studies have reported that the sta
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