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RESEARCH ARTICLE

Open Access

The role of 99mTc‑MIBI SPECT/CT in patients with secondary hyperparathyroidism: comparison with 99mTc‑MIBI planar scintigraphy and ultrasonography Shu‑Qin Jiang†, Ting Yang†, Qiong Zou, Lei Xu, Ting Ye, Yin‑Qian Kang, Wan‑Ru Li, Ju Jiao and Yong Zhang*

Abstract  Background:  This study aimed to compare the sensitivity of 99mTc-MIBI SPECT/CT, 99mTc-MIBI planar scintigraphy and ultrasonography (US) in patients with secondary hyperparathyroidism (SHPT), and to explore the factors that affect the sensitivity of 99mTc-MIBI SPECT/CT. Methods:  In this retrospective study, forty-six patients with SHPT who underwent 99mTc-MIBI planar scintigraphy, 99m Tc-MIBI SPECT/CT and US were enrolled. They underwent surgery within 1 month. We compared the sensitivity of the different imaging methods based on the lesions according to the pathological results. The parathyroid lesions on 99mTc-MIBI SPECT/CT images were divided into missed diagnosis group (MDG) and non-missed diagnosis group (NMDG). We compared the lesion to background ratio (LBR), maximum diameter, volume, the mean CT Houns‑ field unit values (CTmean) and location of lesions between MDG and NMDG. Results:  The sensitivity of 99mTc-MIBI SPECT/CT, 99mTc-MIBI planar scintigraphy and US were 70.30% versus 48.48% versus 61.82%, respectively. The sensitivity of 99mTc-MIBI SPECT/CT combined US was 79.39%, which was higher than 99m Tc-MIBI SPECT/CT with significant difference (P = 0.000). On 99mTc-MIBI SPECT/CT images, the LBR, maximum diam‑ eter and volume of lesions in MDG was smaller than those in NMDG with significant difference (P 

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