The role of cardiopulmonary exercise testing (CPET) in predicting mortality and morbidity in people with congenital hear
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(2020) 4:4
Journal of Congenital Cardiology
REVIEW
Open Access
The role of cardiopulmonary exercise testing (CPET) in predicting mortality and morbidity in people with congenital heart disease: a systematic review and metaanalysis (Protocol) Curtis A. Wadey1, Max E. Weston1, Dan Mihai Dorobantu1, Rod S. Taylor2, Guido E. Pieles1,3,4, Alan R. Barker1 and Craig A. Williams1*
Abstract Background: Numerous studies have measured the prognostic associations between cardiorespiratory fitness and patient outcomes in congenital heart disease, but no systematic review has assessed these associations for all types of congenital heart disease. It is therefore a timely opportunity to syntheses all available data using a systematic review methodology. The aim of this study is to detail the protocol for a systematic review and meta-analysis. Objectives: Within this paper we have developed a protocol for a prognostic factors systematic review and metaanalysis, to assess the role of cardiopulmonary exercise testing/cardiorespiratory fitness, in the prognosis of mortality and morbidity in congenital heart disease. Methods: We have outlined, in detail, the process for this systematic review using the latest accepted methodological guidelines for prognostic factors research, such as the PICOTS system, CHARMS-PF data extraction, QUIPS risk of bias assessments and the prognostic GRADE guidelines (see list of abbreviations). Conclusion: The implications of this review will aid future treatments, interventions and individual patient risk prediction. The publication of this protocol aims to improve scientific rigour by ensuring transparency in the systematic review and meta-analysis process. Keywords: Cardiorespiratory fitness, Exercise test, Mortality, Morbidity, Prognosis, Congenital heart, Systematic review
* Correspondence: [email protected] 1 Children’s Health and Exercise Research Centre, University of Exeter, St Luke’s Campus, Heavitree Road, Exeter, Devon EX1 2LU, UK Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data ma
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