The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective s
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ORIGINAL ARTICLE
The role of circulating tumor cells and K‑ras mutations in patients with locally advanced rectal cancer: a prospective study Abeer A. Bahnassy1 · Yasser A. Abdel‑Azim2 · Somaya Ezzat2 · Mona S. Abdellateif3 · Abdel‑Rahman N. Zekri4 · Marwa Mohanad5 · Asmaa Salama1 · Hussein Khaled6 Received: 11 August 2020 / Accepted: 3 November 2020 © Springer Nature B.V. 2020
Abstract Rectal cancer is a common malignancy with a relatively poor prognosis. We assessed the possible prognostic and predictive role(s) of circulating tumor cells (CTCs) and K-ras mutations in locally advanced rectal carcinoma (LARC) patients. CTCs number and K-ras mutation status were assessed in the Peripheral blood and tumor tissue samples of 60 patients with LARC compared to control group (normal rectal mucosa). Data were correlated to relevant clinico-pathological features, response to treatment, disease free (DFS) and overall survival (OS) rates. K-ras mutations were present in 24/60 (40%) patients. Baseline CTCs (
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