The role of EP-2 receptor expression in cervical intraepithelial neoplasia
- PDF / 1,561,071 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 68 Downloads / 203 Views
ORIGINAL PAPER
The role of EP‑2 receptor expression in cervical intraepithelial neoplasia Elisa Schmoeckel1 · Patricia Fraungruber2 · Christina Kuhn2 · Udo Jeschke1,2,4 · Sven Mahner1,2 · Theresa Maria Kolben3 · Thomas Kolben3 · Theresa Vilsmaier2 · Anna Hester3 · Helene Hildegard Heidegger2 Accepted: 3 August 2020 © The Author(s) 2020
Abstract Prostaglandin induced signalling is involved in different cancers. As previously described, the EP3 receptor expression decreases with increasing stage of cervical intraepithelial lesions (CIN). In addition, in cervical cancer EP3 is an independent prognosticator for overall survival and correlates with FIGO stages. Currently the role of Prostaglandin 2 receptor 2 (EP2) in CIN is unknown. The aim of this study was to analyse the expression of EP2 for potential prognostic value for patients with cervical dysplasia. EP2 expression was analysed by immunohistochemistry in 33 patient samples (CIN1–3) using the immune-reactivity scoring system (IRS). Expression levels were correlated with clinical outcome to analyse prognostic relevance in patients with CIN2. Data analysis was performed using non parametric Kruskal–Wallis and Spearman rank sum test. Cytoplasmic expression levels of EP2 correlated significantly (p
Data Loading...
