Prevalence and distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia in China: a meta-ana
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REVIEW
Prevalence and distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia in China: a meta‑analysis Junya Zhang1 · Keyan Cheng1 · Zhilian Wang1 Received: 2 November 2019 / Accepted: 2 September 2020 © The Author(s) 2020
Abstract Background and aim Data on type-specific human papillomavirus (HPV) are needed to investigate HPV-based screening tests and HPV vaccines. However, Chinese relevant data are insufficient. Therefore, this meta-analysis aimed to summarize and demonstrate the prevalence and distribution of HPV genotypes in cervical intraepithelial neoplasia (CIN) and compensate for the shortage of HPV vaccines in China. Methods The Medline, Embase, and the Cochrane Library databases, as well as references cited in the selected studies, were systematically searched for studies investigating the prevalence and distribution of HPV genotypes between January 2000 and April 2019 in China. Results A total of 8 studies were identified, which comprised 2950 patients with CIN1 and 5393 with CIN2/3. The overall HPV infection rate was 84.37%. The HPV infection rate was significantly higher in the CIN2/3 group (87.00%) than in the CIN1 group (79.56%) (χ2 = 80.095, P 0.05 and I2 was
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