The Serpin Family Proteins with Multiple Functions in Health and Dis

The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking

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erpin Family Proteins with Multiple Functions in Health and Disease

The Serpin Family

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Margarethe Geiger • Felix Wahlmu¨ller • Margareta Furtmu¨ller Editors

The Serpin Family Proteins with Multiple Functions in Health and Disease

Editors Margarethe Geiger Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology Medical University of Vienna Vienna, Austria

Felix Wahlmu¨ller Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology Medical University of Vienna Vienna, Austria

Margareta Furtmu¨ller Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology Medical University of Vienna Vienna, Austria

ISBN 978-3-319-22710-8 ISBN 978-3-319-22711-5 DOI 10.1007/978-3-319-22711-5

(eBook)

Library of Congress Control Number: 2015955182 Springer Cham Heidelberg New York Dordrecht London # Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

Preface

We were just about to organize the 7th International Symposium on Serpin Biology, Structure, and Function (Serpins 2014) when Springer approached us with the idea to edit a book on topics of “vascular biology.” Since the meeting, which then took place in March/April 2014 in Leogang, Austria, was a great success, it was clear to us that a book reviewing recent advances in the field of serpins in connection with the serpin meeting is needed by the scientific community. We therefore invited speakers of that meeting to contribute a chapter to a book about serpins and were very pleased that most of them agreed. In addition we could get on board some renowned scientists who were not able to attend the conference but who nevertheless agreed to contribute a chapter. For those who are not members of the serpin community, the term “serpin” in an acr