Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma
- PDF / 478,636 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 52 Downloads / 194 Views
LABORATORY INVESTIGATION
Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma Shi-yong Wang • Yi-quan Ke • Guo-hui Lu • Zhen-hua Song Li Yu • Sha Xiao • Xin-lin Sun • Xiao-dan Jiang • Zhi-lin Yang • Chang-chen Hu
•
Received: 5 August 2012 / Accepted: 9 February 2013 / Published online: 16 February 2013 Ó Springer Science+Business Media New York 2013
Abstract A previous report has confirmed the existence and clinical significance of vasculogenic mimicry (VM) in glioma. However, its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and, thus, might be unconvincing. The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma. Patients were classified as VM-positive or VM-negative according to CD34 and periodic acid-Schiff staining. The association between VM and the clinical characteristics of the patients was analyzed. Univariate and multivariate analyses were carried out to identify the independent prognostic factors for overall survival using the Cox regression hazard model. Survival times were estimated using the Kaplan–Meier method and compared using the log-rank test. Of all 86 glioblastomas, 23 were found to have VM. The presence of VM in glioblastoma was not associated with gender, age, Karnofsky performance status, hydrocephalus, tumor burden, microvessel density, tumor relapse, or the extent of Shi-yong Wang and Yi-quan Ke contributed equally to this study. S. Wang Y. Ke (&) G. Lu Z. Song X. Sun X. Jiang Z. Yang Department of Neurosurgery, Zhujiang Hospital, National Key Clinic Department, Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Gongye Road 253, Guangzhou 510282, China e-mail: [email protected] L. Yu S. Xiao Department of Pathology, Zhujiang Hospital, Southern Medical University, Gongye Road 253, Guangzhou 510282, China C. Hu Department of Neurosurgery, Shanxi Provincial People’s Hospital, Taiyuan 030012, China
tumor resection. The univariate and multivariate analyses revealed that VM is an independent prognostic factor for overall survival. The median survival time for patients with VM was 11.17 months compared with 16.10 months for those without VM (P = 0.017). In addition to VM, an age of 65 years or older, a KPS of 60 or less, a large tumor burden are significant prognostic factors for patient survival. Our data suggest that VM might be an independent adverse prognostic factor in newly diagnosed GBM, further prospective studies are needed to answer this question. Keywords Vasculogenic mimicry (VM) Glioblastoma Microvessel density (MVD) Survival
Introduction Glioblastoma is the most lethal malignant brain tumor found in humans. Over the past decades, many malignancies have been successfully cured or at least survival was prolonged by multimodal treatments, including optimal surgical resection followed by a combination of postsurgical radiotherapy and chem
Data Loading...
