The usability of quantification of myocardial blood flow by cardiac magnetic resonance for evaluation of cell therapy fo
- PDF / 68,493 Bytes
- 1 Pages / 610 x 792 pts Page_size
- 70 Downloads / 173 Views
BioMed Central
Open Access
Poster presentation
The usability of quantification of myocardial blood flow by cardiac magnetic resonance for evaluation of cell therapy for ischemic cardiomyopathy using a retrograde injection method Satoshi Kunimoto*1, Yasuo Watanabe1, Tadateru Takayama1, Shinichiro Yokoyama1, Yuichi Sato1,2, Ichiro Watanabe1, Satoshi Saito3, Atsushi Hirayama1 and Hajime Sakuma4 Address: 1Nihon University School of Medicine, Tokyo, Japan, 2Health Park Clinic, Takasaki, Gunma, Japan, 3Keiai Hospital, Tokyo, Japan and 4Mie Univ Graduate Sch of Med, Tsu City, Japan * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P110
doi:10.1186/1532-429X-12-S1-P110
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P110 © 2010 Kunimoto et al; licensee BioMed Central Ltd.
Introduction Bone marrow cells implantation (BMI) has been reported to efficiently improve ischemic cardiomyopathy (ICM). However, the method of accurate evaluation of the efficacy has not built up yet.
Purpose The purpose of our study was to confirm the usability of fully quantitative analysis of myocardial blood flow (MBF) by myocardial perfusion magnetic resonance imaging (P-MRI) as compared with single-photon emission computed tomography (SPECT) to detect the effect of BMI therapy.
Methods The candidate of this study was 5 cases of ICM (All Male, 64.3 + 7.7 y/o). Bone marrow Mononuclear cells (BMMNC) were quickly injected retrogradely via the coronary vein into the myocardium of LAD area through the infusion catheter. The number of injected BMMNC is 1.47 + 0.35 × 108. P-MRI and SPECT were performed before and after procedure. P-MRI was obtained with a saturation recovery balanced TFE sequence, by injecting 0.05 mmol/ kg of Gd-DTPA during vasodilator stress and at rest. Dual bolus method was used to correct for blood saturation. Absolute MBF was quantified by using a model based Pat-
lak analysis, with correction for flow-dependent alteration in extraction fraction of Gd-DTPA. Therapy evaluation were made, which were 1) Symptom of Angina pectoris with CCS scoring. 2) SPECT score: Summed rest Score (SRS), Summed stress score (SSS), Summed Difference Score (SDS). 3) BMF and Coronary Flow Reserve (CFR) from P-MRI.
Results BMI was performed successfully in all cases. BMI improved chest discomfort frequency, but cardiac function and evaluation score by SPECT did not show improvement. There were no significantly BMF increases detected by P-MRI. But P-MRI indicated the increasing trend of BMF in LCX perfused area, instead of LAD. CFR data indicated increasing trend in LCX area (P = 0.07).
Conclusion In this study, there was no significant difference detect
Data Loading...
