The use of retinoic acid in association with microneedling in the treatment of epidermal melasma: efficacy and oxidative
- PDF / 957,829 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 100 Downloads / 150 Views
ORIGINAL PAPER
The use of retinoic acid in association with microneedling in the treatment of epidermal melasma: efficacy and oxidative stress parameters Clarissa L. M. da Silva Bergmann1,2 · Daniela Pochmann1 · Julio Bergmann3 · Fernanda Brasil Bocca1 · Isabel Proença1 · Jessica Marinho1 · Alexandre Mello1 · Caroline Dani1 Received: 9 October 2019 / Revised: 3 September 2020 / Accepted: 12 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract This study aimed to evaluate the effectiveness of isolated treatment with retinoic acid and its combination with the microneedling technique in facial melasma, seeking to associate these results with possible oxidative damage. This is a blinded randomized clinical trial with 42 women with facial melasma (skin phototype I–IV), randomized into Group A (microneedling and 5% retinoic acid) or Group B (5% retinoic acid alone). Four procedures were applied with 15 days intervals (4 blood collections). Clinical improvement was assessed using the Melasma Area Severity Index (MASI). Serum oxidative stress levels were evaluated by protein oxidation (carbonyl), lipid peroxidation (TBARS) and sulfhydryl groups, as well as enzyme activities of superoxide dismutase (SOD) and catalase (CAT). The statistical analyzes were performed by generalized estimation equation (GEE). There was a reduction in MASI scale and TBARS levels in both groups over time (p
Data Loading...
